No, blaming a GPS does not absolve someone of fault in an accident. If they made a negligent mistake and caused a crash, the fault still lies with them.
For example, say that you were driving down a one-way street when another driver made a turn off a side street, began heading the wrong direction and caused a head-on car accident. When you got out of the vehicle to ask them what they were thinking or what they were doing, they informed you that their GPS told them to turn that direction.
As it turns out, the road design has been changed in the last few years. The street used to be a two-way street, but was changed to a one-way street, and the GPS software was never updated. While it makes sense that the driver would blame their GPS for the crash, they are still personally responsible.
Making reasonable decisions
The thing to remember is that drivers are still ultimately in charge of all the decisions that they make. These decisions must be reasonable, and they have to use common sense.
In this specific example, the person behind the wheel still should have seen the wrong-way signs or the one-way traffic signs. They should have noticed that oncoming traffic was in their lane. They are still responsible for determining if they are driving in the correct direction, no matter what the GPS tells them.
Much like a paper map, a GPS device is a tool. It can be helpful, but drivers are still making their own decisions based on that guidance, and they are responsible for the choices that they make.
This means that you can likely still seek financial compensation from the other driver if you suffered injuries in the crash, so make sure you know what legal steps to take.